Incredibly damaging Rendering Bug (Upscalers crash?)

Bug Report ID: #2225061210

This bug occured while inside the Ardura Caravan; to my knowledge this bug was introduced in 0.3 and it has not been fixed (I've made another post about this last expansion).

At random points, rendering breaks and the game becomes unplayable due to rendering errors. I presume this is an issue with the upscaling methods because they stop working when the bug occurs.

The bug manifests either from models bugging out and rendering stretched across the whole screen, the screen going black and things not rendering (only the health/mana orbs and hotbars), Skill Tree icons flickering and not rendering correctly, item art being broken etc.

Edit: this bug also occurs in POE1 when using FSR upscaling since 3.27 Keepers of the Flame.

The game must be exited every time this happens, logging in and out does not fix the issue.